College of Pharmacy
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Welcome to the MCP NMR Facility

The NMR facility, located in room B71 in the College of Pharmacy building, serves more than 150 research graduate students and post-doctoral associates from the Department of Medicinal Chemistry and Pharmacognosy.

Presently, the NMR facility houses two (2) high-resolution NMR spectrometers:

1) 400 MHz Bruker DPX-400 NMR spectrometer equipped with a 5 mm QNP (4-nucleus) probe for 1H, 13C, 19F and 31P observation. The probe is switchable between nuclei using a software controlled switching box. Most of the NMR experiment run on this instrument, including gradient selected 2-D experiments, can be run in a manual or semi-automatic mode. This instrument is also equipped with an auto-sampler which allows unattended operation of up to 60 samples. This probe is also equipped with a variable temperature unit which is capable of operation in the range of -150°C to + 200°C. The host computer (PC) is currently running XWIN-NMR v. 3.1 software.

2) 400 MHz Bruker AVANCE-400 spectrometer equipped with a 5mm ATM (auto frequency tune and match) probe which allows automatic frequency tuning and impedance match on the decouple channel (1H) as well as the broad band (BB) observe channel (31P to 109Ag). Most of the NMR experiments run on this instrument, including gradient selected 2-D experiments and selective 1-D experiments, can be run in a manual or semi-automatic mode. The ATM probe is equipped with a variable temperature unit which is capable of operation in the range of +35°C to +200°C. The host computer (PC) is running XWIN-NMR v. 3.5 software.

The AVANCE console described above is equipped with gradient amplifiers and digital shaped pulse generator for selective excitation. Non-gradient versions of the 2-D experiments are also available. Bruker most recent TopSpin software v1.3, for acquisition and processing of NMR data, will be available soon. The system also features updated BACS-60 auto sampler for unattended runs.